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	Provedor de dados BJMBR (5) Autor Brink,P.R. (2) Christ,G.J. (2) Carvalho,M.H.C. (1) Fortes,Z.B. (1) Gerová,M. (1) Kristek,F. (1) Nigro,D. (1) Ricotta,J. (1) Tostes,R.C. (1) Mais... Palavra-chave Vascular smooth muscle (5) Gap junctions (2) Hypertension (2) Angiotensin (1) Artery (1) Bay K 8644 (1) Calcium (1) Calcium channels (1) Connexin43 (1) Endothelin-1 (1) Endothelium nitric oxide (1) Endothelium-derived hyperpolarizing factor (1) Estrogen (1) Extracellular matrix (1) Intercellular communication (1) Morphometry (1) Nitric oxide (1) Offspring (1) Potassium channels (1) Rat aorta (1) Mais... Tipo do documento Info:eu-repo/semantics/article (4) Info:eu-repo/semantics/other (1) Ano 2004 (1) 2003 (1) 2000 (2) 1997 (1) País Brazil (5) Idioma Inglês (5)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 5 Primeira ... 1 ... Última Biophysical characteristics of gap junctions in vascular wall cells: implications for vascular biology and disease BJMBR Brink,P.R.; Ricotta,J.; Christ,G.J.. The role gap junction channels play in the normal and abnormal functioning of the vascular wall is the subject of much research. The biophysical properties of gap junctions are an essential component in understanding how gap junctions function to allow coordinated relaxation and contraction of vascular smooth muscle. This study reviews the properties thus far elucidated and relates those properties to tissue function. We ask how biophysical and structural properties such as gating, permselectivity, subconductive states and channel type (heteromeric vs homotypic vs heterotypic) might affect vascular smooth muscle tone. Tipo: Info:eu-repo/semantics/article Palavras-chave: Vascular smooth muscle; Gap junctions. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400007 Calcium handling by vascular myocytes in hypertension BJMBR Calcium ions (Ca2+) trigger the contraction of vascular myocytes and the level of free intracellular Ca2+ within the myocyte is precisely regulated by sequestration and extrusion mechanisms. Extensive evidence indicates that a defect in the regulation of intracellular Ca2+ plays a role in the augmented vascular reactivity characteristic of clinical and experimental hypertension. For example, arteries from spontaneously hypertensive rats (SHR) have an increased contractile sensitivity to extracellular Ca2+ and intracellular Ca2+ levels are elevated in aortic smooth muscle cells of SHR. We hypothesize that these changes are due to an increase in membrane Ca2+ channel density and possibly function in vascular myocytes from hypertensive animals. Several... Tipo: Info:eu-repo/semantics/other Palavras-chave: Vascular smooth muscle; Hypertension; Calcium; Voltage-operated calcium channels; Vascular reactivity; Bay K 8644. Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000300004 Effects of estrogen on the vascular system BJMBR Tostes,R.C.; Nigro,D.; Fortes,Z.B.; Carvalho,M.H.C.. The cardiovascular protective actions of estrogen are partially mediated by a direct effect on the vessel wall. Estrogen is active both on vascular smooth muscle and endothelial cells where functionally competent estrogen receptors have been identified. Estrogen administration promotes vasodilation in humans and in experimental animals, in part by stimulating prostacyclin and nitric oxide synthesis, as well as by decreasing the production of vasoconstrictor agents such as cyclooxygenase-derived products, reactive oxygen species, angiotensin II, and endothelin-1. In vitro, estrogen exerts a direct inhibitory effect on smooth muscle by activating potassium efflux and by inhibiting calcium influx. In addition, estrogen inhibits vascular smooth muscle cell... Tipo: Info:eu-repo/semantics/article Palavras-chave: Sex hormones; Estrogen; Vascular smooth muscle; Endothelium nitric oxide; Endothelium-derived hyperpolarizing factor; Angiotensin; Endothelin-1; Calcium channels; Potassium channels. Ano: 2003 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000900002 Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication BJMBR Christ,G.J.; Brink,P.R.. Connexin43 (Cx43) is a major gap junction protein present in the Fischer-344 rat aorta. Previous studies have identified conditions under which selective disruption of intercellular communication with heptanol caused a significant, readily reversible and time-dependent diminution in the magnitude of <FONT FACE="Symbol">a</font>1-adrenergic contractions in isolated rat aorta. These observations have indentified a significant role for gap junctions in modulating vascular smooth muscle tone. The goal of these steady-state studies was to utilize isolated rat aortic rings to further evaluate the contribution of intercellular junctions to contractions elicited by cellular activation in response to several other vascular spasmogens. The effects of... Tipo: Info:eu-repo/semantics/article Palavras-chave: Gap junctions; Connexin43; Rat aorta; Vascular smooth muscle; Intercellular communication. Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000400008 Hypotrophy of conduit artery walls of the offspring of nitric oxide-defective rats BJMBR Kristek,F.; Gerová,M.. The objective of the present study was to investigate the structure of the arterial walls of the offspring stemming from nitric oxide (NO)-defective hypertensive parents. The parents were treated with N G-nitro-L-arginine methyl ester (40 mg kg-1 day-1) for 5 weeks. Blood pressure was measured noninvasively in six 30-day-old rats and nine age-matched controls. The cardiovascular system was perfused with glutaraldehyde at 120 mmHg. The thoracic aorta and carotid artery were processed for electron microscopy, and geometry was determined by light microscopy. Endothelial cells, smooth muscle cells (SMC) and extracellular matrix (ECM) were determined by the point counting method in electron micrographs of the carotid artery. The blood pressure of experimental... Tipo: Info:eu-repo/semantics/article Palavras-chave: Artery; Nitric oxide; Offspring; Hypertension; Vascular smooth muscle; Extracellular matrix; Morphometry. Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000400018 Registros recuperados: 5 Primeira ... 1 ... Última

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